Volume : VIII, Issue : V, May - 2019

OXIDATIVE STRESS IN PRE–ECLAMPSIA – MDA & IMA AS BIOMARKERS

Dr. Navanil Roy, Dr. Mrinal Gupta

Abstract :

BACKGROUND ; Pre–eclampsia (PE) is a disorder of pregnancy and a common cause of foetal and maternal death. MDA & Ischemia Modified Albumin (IMA) has emerged as a marker in different diseases where ischemia is the origin or consequence behind disease pathology but studies have been few. Reliable biochemical markers for identifying patients at risk of PE can have a better impact on maternal health and better management. MATERIALS & METHODS:;30 patients with PE were selected for the study and compared with 30 pregnant healthy controls. IMA and Malondialdehyde (MDA) with other routine biochemical markers were estimated in these patients. The results were then statistically analysed. RESULTS ;IMA levels were found significantly raised in PE patients as compared to normal pregnant controls (p value<0.001). A significant correlation was also found between IMA levels and MDA levels in PE (r= 0.3) CONCLUSION;IMA which is generated by hypoxia/ischemia driven oxidative stress is also raised in PE and hence can be used as a biomarker in PE. Further studies are needed to establish the relationship between IMA and the disease process and its association with severity of disease.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

OXIDATIVE STRESS IN PRE-ECLAMPSIA‾MDA & IMA AS BIOMARKERS, DR. NAVANIL ROY, DR. MRINAL GUPTA INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-5 | May-2019

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