Oxidative Stress of Bisphenol–A and its Adverse Effect on the Liver of Fresh Water Fish, Oreochromis Mossambicus

Chitra K.C.; Sr. Maiby

Volume : III, Issue : VII, July - 2014

Oxidative Stress of Bisphenol–A and its Adverse Effect on the Liver of Fresh Water Fish, Oreochromis Mossambicus

Chitra K. C. , Sr. Maiby

Abstract :

Bisphenol A at sub lethal concentration (1 mg/ L) was given to ten adult freshwater fish, Oreochromis mossambicus for 10 and 20 days maintaining the controls. Exposure to bisphenol A significantly decreased the activities of superoxide dismutase, catalase and glutathione reductase with increased level of lipid peroxidation in time-dependent manner when compared to control groups thereby indicating that bisphenol A induces oxidative stress in liver of Oreochromis. The activity of alkaline phosphatase was significantly decreased in liver of treated fish due to the decreased state of inter and intracellular memane transport owing to the toxicity of bisphenol A. It also resulted in hepatic lesions including degeneration, necrosis, irregular position of nuclei and vacuolization of cell cytoplasm. The present findings suggest that bisphenol A exerts its toxicity effect in liver of fish by the generation of oxygen free radicals thus inducing lipid peroxidation and modifying the antioxidant status in time-dependent manner.