PARENTERAL IRON TREATMENT IN PREGNANCY: Comparision of High-dose Ferric carboxymaltose vs. Iron sucrose.

Dr. Reena Patel; Dr. Aniket Tripathi; Dr. Parul Shah; Dr. Kruti Delivala; Dr. Shailee Bhatt; Dr. Divyanshi Shani

Volume : VIII, Issue : IX, September - 2019

PARENTERAL IRON TREATMENT IN PREGNANCY: Comparision of High-dose Ferric carboxymaltose vs. Iron sucrose.

Dr. Reena Patel, Dr. Aniket Tripathi, Dr. Parul Shah, Dr. Kruti Delivala, Dr. Shailee Bhatt, Dr. Divyanshi Shani

Abstract :

Objective: The use of oral iron substitution has not shown to be sufficient for treatment of severe iron deficiency anemia in pregnancy. Ferric carboxymaltose is a new intravenous (i.v.) iron formulation which has been deemed to be better in efficacy and as safe as iron sucrose. Our study was aimed to assess adverse effects and tolerance of ferric carboxymaltose compared to i.v. iron sucrose in pregnant women. Methods: Our study was a retrospective study of 104 pregnant women who were treated either with ferric carboxymaltose or iron sucrose for iron–deficiency anemia and who did not tolerate oral iron, or sufficient hemoglobin rise after oral iron treatment was not achieved, or there was need for rapid hemoglobin reconstitution. Primary endpoint was to evaluate safety and tolerability in mothers. Secondary endpoint was to assess efficacy of the treatment and exclude safety concerns for the foetus. Results: The incidence of drug–related side effects was low both groups. Mild adverse events occurred in 7.7% for ferric carboxymaltose and in 10.8% for iron sucrose. The mean rise of hemoglobin value was 1.5 g/dL for ferric carboxymaltose and 1.1 g/dL for iron sucrose. Conclusion: The use of Ferric carboxymaltose in antenatal women is well tolerated and safe. Ferric carboxymaltose is as safe as iron sucrose but it has an advantage that it can be given in a much higher dose in a single sitting which increases patient compliance and the need for repeated administrations is reduced. Hence Ferric carboxymaltose is the i.v. drug of choice in 2nd & 3rd trimester of pregnancy.