Pathophysiology and Clinical assessment of anemia in Systemic lupus erythematous.

RAJENDRA.V. BHAGWAT; NANDKUMAR.N. PATIL

Volume : VI, Issue : III, March - 2017

Pathophysiology and Clinical assessment of anemia in Systemic lupus erythematous.

Rajendra. V. Bhagwat, Nandkumar. N. Patil

Abstract :

Hematological abnormalities are very common in systemic lupus erythematosus. Anemia is most common hematological abnormality in systemic lupus erythematous. Anemia is found in approximately 50% of patients, with anemia of chronic disease being the most common form. Impaired response of the bone marrow to erythropoietin and sometimes presence of antibodies against erythropoietin may contribute to the pathogenesis of this type of anemia. Some Patients with systemic lupus erythematous may have autoimmune haemolytic anemia which usually belong to a distinct category, which is associated with anticardiolipin antibodies, antinuclear antibodies sometimes with anti Dsdna antibody. In patients with systemic lupus erythematous thrombosis, thrombocytopenia and renal involvement, often occur in the context of secondary antiphospholipid syndrome. Finally, as recently suggested, auto antibodies, T Lymphocytes and deregulation of the cytokines network can affect bone marrow erythopoiesis leading to anemia.