Volume : III, Issue : I, January - 2014
Pattern of Adverse Drug Reactions Due to Cancer Chemotherapy in Tertiary Care Teaching Hospital in Gujarat
Yash N. Goyal, Krunal C Solanki, Rusva A Mistry, Nisarg D Joshi, Anil P Singh, Maganlal V Gajera
Abstract :
Aim: To assess the pattern of adverse drug reactions in patients receiving cancer chemotherapy.
Methods: A prospective, observational study was carried out for duration of twelve months. Clinical and treatment data were collected from patients who underwent cancer chemotherapy during the study period. CDSCO forms were used to record the ADRs. Causality, severity and preventability were assessed by suitable scales.
Result: Total of 199 ADRs were noted among 105 patients. Out of them 57(54.29%) were males and 48(45.71%) were females. The most common SOC was gastrointestinal disorders (35.17%). Platinum (54.29%) and antimetabolites(48.71%) were most common drug classes responsible for ADRs. According to WHO causality assessment most of the ADRs were “possible” 78(39.19%). Hartwig and Siegel severity scale shows 53.26% ADRs were “moderate”. Shumock and Thornton scale shows 171(85.93%) ADRs were “not preventable”.
Conclusion: Early detection of drug toxicity helps to treat the patient and modify the doses or the drug regimen to minimize toxic effects.
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DOI : 10.36106/ijsr
Cite This Article:
Yash N. Goyal, Krunal C Solanki, Rusva A Mistry, Nisarg D Joshi, Anil P Singh, Maganlal V Gajera Pattern of Adverse Drug Reactions Due to Cancer Chemotherapy in Tertiary Care Teaching Hospital in Gujarat International Journal of Scientific Research, Vol.III, Issue.I January 2014
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Yash N. Goyal, Krunal C Solanki, Rusva A Mistry, Nisarg D Joshi, Anil P Singh, Maganlal V Gajera Pattern of Adverse Drug Reactions Due to Cancer Chemotherapy in Tertiary Care Teaching Hospital in Gujarat International Journal of Scientific Research, Vol.III, Issue.I January 2014
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