PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF AEGLE MARMELOS IN PARACETAMOL INTOXICATED RATS

Rojin T.S; Padma Shetty; Sukanya Shetty; Rajendra Holla

Volume : VIII, Issue : V, May - 2019

PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF AEGLE MARMELOS IN PARACETAMOL INTOXICATED RATS

Rojin T. S, Padma Shetty, Sukanya Shetty, Rajendra Holla

Abstract :

Objective: To evaluate the hepatoprotective effect of Aegle marmelos (AM) on paracetamol induced hepatotoxicity and to study the phytochemical composition by GCMS analysis. Methods: The rats were administered with ethanolic leaf extract of AM (200mg/kg b.wt) prior to paracetamol (2g/kg b.wt) for 21 days.Animals were sacrificed using ether, blood & liver were collected.Biochemical estimation and histopathological analysis were performed. Results: The pre–treatment with A. marmelos in paracetamol intoxicated rats has shown improvement in the levels of oxidative stress parameters and there was significant reduction of serum marker levels. Extensive hepatic necrosis was evident in paracetamol treated rats, whereas no necrosis observed in AM treated rats. 22 constituents were eluted from AM extract. n–Hexadecenoic acid and phytol were the major compounds. Conclusion: The results obtained in the present study suggest that ethanolic extract of AM possess significant hepatoprotective activity against paracetamol induced hepatotoxicity.