Pilot Study to Find out the association of total testosterone with Coronary artery disease among the South Indian Population

Dr.Santhini Gopalakrishnan.S; Dr.E.Malligai; Dr.Sandeep U; Mr.S.K Murugavel; Mr.Venkat Siddarth; Dr.Pitcahai Ansar Khalifullah; Mrs.KJ Christina; Mr. Vinoda kumar H. R.

Volume : VI, Issue : XII, December - 2017

Pilot Study to Find out the association of total testosterone with Coronary artery disease among the South Indian Population

Dr. Santhini Gopalakrishnan. S, Dr. E. Malligai, Dr. Sandeep U, Mr. S. K Murugavel, Mr. Venkat Siddarth, Dr. Pitcahai Ansar Khalifullah, Mrs. Kj Christina, Mr. Vinoda Kumar H. R.

Abstract :

Background:Atherosclerotic Coronary Artery Disease(CAD) is a leading cause of mortality and morbidity worldwide.Men have twice the risk of getting attacks of CAD than women.The role of testosterone in the pathogenesis of CAD has little been studied.My aim is to study the influence of testosterone among men and the occurrence of CAD.

Aim:The association between low testosterone levels and coronary artery disease in urban male population of Chennai.

Objective:To find out the effects of low testosterone levels in predisposing to CAD in males.

Study design:The study was a case control study conducted among 97 subjects(47cases and 50 controls) among the patients attending the cardiac OPD of Chettinad Hospital and Research Institute for a period of 6 months

Inclusion criteria:

Cases:Patients with CAD with significant lesion in the coronary arteries.

Controls:Normal healthy individuals.

Exclusion criteria: H/o hypogonadism,h/o radiation exposure, drug abuse,athletes.

Methodology:After obtaining consent, cases and controls are selected based on clinical history and angiographic findings.They are requested to give 5 ml of blood. Blood is collected in red topped vacutainer which should be centrifuged and the following parameters analysed.

Statistical Analysis:The statistical analysis was done using the SPSS version 21.

Result: Testosterone levels were lower in men with Coronary artery disease than normal healthy individuals and was found to be statistically significant(p<0.05).

Conclusion:A low plasma testosterone level is associated with high percent risk of development of coronary artery disease suggesting the protective effect of testosterone on endothelium