PIPER LONGUM, SYZYGIUM AROMATICUM EXTRACT AS SUPPLEMENTARY DRUG FOR REVERSAL OF PLASMID GENERATED MULTIPLE DRUG RESISTANCE.

Lochana  Kovale; Suresh Patil; Chaitanya Raorane; Jagadavva Pujare; Snehal Kanse; Dhananjay Desai

Volume : V, Issue : I, January - 2016

PIPER LONGUM, SYZYGIUM AROMATICUM EXTRACT AS SUPPLEMENTARY DRUG FOR REVERSAL OF PLASMID GENERATED MULTIPLE DRUG RESISTANCE.

Lochana Kovale, Suresh Patil, Chaitanya Raorane, Jagadavva Pujare, Snehal Kanse, Dhananjay Desai

Abstract :

Multiple Drug Resistance (MDR) in microbial strains has become a severe health threat to human kind and one of the biggest challenges to global drug discoverer programs. MDR genes are usually located on R–plasmid. Present investigation is aimed to evaluate the activity of alcohol and aqueous extract of Piper longum and Syzygium aromaticum as a plasmid curing agent by supplementing it with drugs. study was carried out on Ampicilin resistant Escherichia coli which encodes resistance with plasmid encoded gene. Within this extracts, Piper longum shows 12% plasmid curing and Syzygium aromaticum shows 09% plasmid curing