PLACENTAL APOPTOSIS AND ITS CORRELATION WITH SEVERITY OF DISEASE IN PREECLAMPSIA AND ECLAMPSIA

Name: IJSR - International Journal of Scientific Research
Address: 303, Maharana Pratap Complex, Opp. Kapadia Guest House, B/H V.S.Hospital, Paldi, Ahmedabad, 380006, India
Telephone: +91 88 66 00 3636
Price range: $10 to $100 USD

Ruchi Sinha; L.K. Pandey; Sulekha Pandey; K.K. Tripathi

Volume : IV, Issue : X, October - 2015

PLACENTAL APOPTOSIS AND ITS CORRELATION WITH SEVERITY OF DISEASE IN PREECLAMPSIA AND ECLAMPSIA

Ruchi Sinha, L. K. Pandey, Sulekha Pandey, K. K. Tripathi

Abstract :

To determine placental apoptosis in pregnancies complicated with preeclampsia and eclampsia and to correlate it with the severity of disease process. A Prospective cohort study in pregnant women attending the antenatal clinic and emergency services in University teaching hospital, Institute of Medical Sciences, Varanasi, India. The placental apoptosis was determined by calculating the apoptosis (%) through TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay.Placental apoptosis was significantly higher in pre–eclampsia and eclampsia as compared to controls (p<0.001). Placental apoptosis and systolic blood pressure (R2 = 0.669) and diastolic blood pressure (R2 = 0.796) had a linear correlation. The level of biochemical markers correlated with each other but not with the extent of apoptosis in cases.Increase in apoptosis correlated with rise in systolic and diastolic blood pressure and severity of disease process.