Platelet Functions and Prothrombotic Factors study in Cerebrovascular Accidents: A Tertiary Care hospital based study at RIMS Ranchi

Dr Manish Kumar; Dr J.K Mitra

Volume : VIII, Issue : VII, July - 2019

Platelet Functions and Prothrombotic Factors study in Cerebrovascular Accidents: A Tertiary Care hospital based study at RIMS Ranchi

Dr Manish Kumar, Dr J. K Mitra

Abstract :

Introduction: According to WHO, globally cereovascular accident is third commonest cause of mortality and fourth leading cause of disease burden. Ischemic cereovascular accident is the most common cereovascular disease, most often due to atherothrombotic disease and uncommonly by disorder of hyper–coagulation. Disorders of coagulation leading to thrombosis are approximately 1% of all ischemic cereovascular accident and 4–8% of young cereovascular accident. Similarly combined deficiency lead to hypercoagulable state and rarely present as cereovascular accident.[1] Aims and Objectives: The present study was undertaken to assess the role of platelet functions (Platelet Count, platelet volume and platelet aggregation) and antithrombotic factors (protein C, protein S and Homocysteine) in the pathogenesis of cereovascular accident. Materials and Methods: A total of 50 patients coming to with cereovascular accidents and 50 age and sex matched controls were included. The cases and controls included in this study were investigated for following parameters: Protein C and protein S were estimated by Coagulometric Assay, Homocysteine estimation was done by Semi–auto analyser, Platelet count and platelet volume were estimated by automated cell counter, Platelet aggregation with ADP by using optical Aggregometer and for PT/APTT estimation. Results: Levels of Protein C and Protein S were significantly decreased whereas Homocysteine was significantly raised in stroke patients. Mean platelet Volume was increased and platelet count reduced in ischemic stroke patients. Platelet aggregation with 5�M ADP was reduced in ischemic and hemorrhagic stroke. Conclusion: Protein C, Protein S, MPV and Homocysteine levels may be useful in diagnosing the ischemic stroke. Platelet count and MPV are inversely proportional to each other in case of ischemic stroke whereas platelet aggregation with 5�M ADP is reduced in both ischemic and hemorrhagic stroke.