Platelet parameters in acute STEMI cases with and without co-morbidities.

Dr. Murari. Apuroopa; Dr. Thallury. Shirin kamal; Dr. Mahankali. Pranathi; Dr. D. Naveen Chandra Rao; Dr. D.Ranga rao

Volume : VIII, Issue : II, February - 2019

Platelet parameters in acute STEMI cases with and without co-morbidities.

Dr. Murari. Apuroopa, Dr. Thallury. Shirin Kamal, Dr. Mahankali. Pranathi, Dr. D. Naveen Chandra Rao, Dr. D. Ranga Rao

Abstract :

Introduction: Coronary artery disease (CAD) is an epidemic and is the most common cause of mortality worldwide. Majority of deaths from CAD result from acute coronary syndrome (ACS). Generalised platelet activation occurs before an acute coronary event. Central to the pathogenesis of occlusive arterial disease is the activation of platelets at sites of vascular injury via pathologically exaggerated and deregulated versions of protective mechanisms involved in hemostasis. Aim: To study the changes in platelet volume indices in ST–Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: This is a cross sectional study conducted in tertiary care hospital and research center in Andhra Pradesh during a time period of one year (Jan 2018– Dec2018). All the patients diagnosed with acute STEMI were included in the study and their platelet indices were compared with those of controls having a normal electrocardiogram. A total of 77 cases and 77 controls were included in the study. Cases were again grouped into those with co–morbid conditions and those without co–morbid conditions. Results: A total of 77 cases with acute STEMI and 77 controls were included in the study.The mean age of patients was 61.3�10yrs with range from 45–80yrs. The mean age of control group was 62.3�10yrs. Out of 77 cases 78% were males, 22% were females. 65 cases have associated one or more co–morbid conditions considered in the sutdy, 12 cases were without any of them. The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.9�3) as compared to controls (8.5�0.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.005). Conclusion: Platelet volume indices provides an important, simple, effortless and cost–effective tool which can be useful in predicting an impending acute coronary event.