IJSR - International Journal of Scientific Research

Dr Amrita Singh; Dr. Abhishek Chauhan; Dr. Gaurav Raj; Dr. Ragini Singh

Volume : VIII, Issue : VIII, August - 2019

PRE AND POST TRANSARTERIAL CHEMOEMBOLISATION ASSESSMENT IN LIVER TUMOR BY MULTIPHASIC CT ANGIOGRAPHY: A PROSPECTIVE OBSERVATIONAL STUDY

Dr Amrita Singh, Dr. Abhishek Chauhan, Dr. Gaurav Raj, Dr. Ragini Singh

Abstract :

Background: Transarterial chemoembolization (TACE) is the most common treatment modality for treating patients of large unresectable hepatocellular carcinoma (HCC). Materials and Methods: A total of 28 patients of HCC were included. Multiphasic computed tomography (CT) scan was done to see the feeding vessel and its feasibility for chemo embolization. Conventional TACE was done using doxorubicin 50–75 mg and 10 ml lipiodol followed by gelfoam embolization with standard protocol. Drug eluting beads (DEB)–TACE was also used in some patients. Results: Out of 28 patients, right hepatic artery was main feeding vessel in most of the patients, mean tumor feeding artery diameter was 1.61mm and mean tumor size was 5.47 cm. After three months of follow up mean tumor necrosis was 93.75% (p value <0.01), and mean alpha fetoprotein was 30.89IU/ml with p value of <0.01 (mean baseline was 6625.28IU/ml). Conclusions: Multiphasic CT scan is a very good tool for tumor vascularity description and the basic step of successful TACE. TACE is a safe and effective procedure and has become an established palliative treatment for unresectable HCC