Pregnancy outcomes and risk factors identification with Group-B Streptococcus infection : A clinical study

Nazma Akter; Xiaohua Luo; Most. Runa Parvin; Ahmed Ferdous

Volume : VIII, Issue : XII, December - 2019

Pregnancy outcomes and risk factors identification with Group-B Streptococcus infection : A clinical study

Nazma Akter, Xiaohua Luo, Most. Runa Parvin, Ahmed Ferdous

Abstract :

Objective: The present study was undertaken to study the prevalence, risk factors and pregnancy outcomes of GBS colonization at their third trimester. Materials & Methods: The present study was a prospective, hospital–based study conducted at the Third Affiliated Hospital of Zhengzhou University of China, between January 2018 to December 2018 and Mother & Child Community Hospital, Bogra, Bangladesh between June 2018 to September 2019. A total of 995 pregnant women from Bangladesh and 1090 pregnant women from China between their 35–37 weeks of gestation were consecutively included in the study. Rectovaginal swab was collected to determine whether they carry GBS or not. Then both groups of pregnant women (pregnant women with and without GBS) were prospectively followed to see the maternal outcomes. Immediately after delivery (within 1 hour), the aural swab from the neonates with GBS positive mothers were collected in delivery or room to see GBS positivity. Results: In the present study 15% of the Bangladeshi pregnant women and 50% of Chinese women had rectovaginal colonization of GBS. In multivariate analysis, GDM, PIH and oligohydramnios emerged as independent predictors of GBS colonization. Although Bangladeshi data demonstrated adverse pregnancy outcomes like PROM and clinical chorioamnionitis in pregnant women with GBS colonization, Chinese data did not prove so. About 16 and 19% of the Neonates with maternal GBS colonization in Bangladeshi and Chinese samples respectively were GBS positive. Conclusion: The study concluded that rectovaginal colonization of GBS during pregnancy is no less and the risk factors for colonization of GBS are GDM, PIH and oligohydramnios. A sizable proportion of neonates (one in six) with maternal GBS positivity may have neonatal GBS positivity.