Prevalence of antichlamydial antibodies in women with infertility and its association with tubal factors

Dr. Vinita Sarbhai; Dr. Mohini Paul; Dr. Swatilekha Karmakar

Volume : VI, Issue : VI, June - 2017

Prevalence of antichlamydial antibodies in women with infertility and its association with tubal factors

Dr. Vinita Sarbhai, Dr. Mohini Paul, Dr. Swatilekha Karmakar

Abstract :

Introduction: The tubal and peritoneal pathology due to PID are the foremost cause of infertility in developing countries and Chlamydia Trachomatis is an important causative agent. Due to asymptomatic nature, there is delay in diagnosis; hence better understanding of its role in infertility is imperative. Method: 50 infertile women were subjected to anti chlamydial IgG and IgA antibodies by ELISA, and the relationship to tubal damage was analysed. Results: 21 (42%) of infertile women were sero positive. A significant correlation of sero–positivity with secondary infertility, tubal factors and adhesions was observed. The sensitivity, specificity, positive predictive value and negative predictive value of anti Chlamydial antibodies in prediction of tubal infertility were 85.71%, 68.97%, 66.67%, and 86.96%. Conclusion: The timely diagnosis of Chlamydia infection by detection of specific anti–Chlamydial antibodies by ELISA is a simple, valuable, non–invasive, diagnostic procedure and hence it should become an integral part of infertility work up.