Prevalence of dermatophytoses and their antifungal susceptibility in a tertiary care hospital of North India.

Dr Stuti Kansra; Dr Pushpa Devi; Dr Shailpreet Sidhu; Dr Anuradha Malhotra

Volume : V, Issue : III, March - 2016

Prevalence of dermatophytoses and their antifungal susceptibility in a tertiary care hospital of North India.

Dr Stuti Kansra, Dr Pushpa Devi, Dr Shailpreet Sidhu, Dr Anuradha Malhotra

Abstract :

Dermatophytoses is the infection of keratinised tissues caused by fungal species of genera Trichophyton, Epidermophyton and Microsporum, commonly known as dermatophytes . Various antifungal agents both topical and systemic have been introduced into clinical practice for effectively treating dermatophytic conditions. The present study aims at determining the susceptibility patterns of dermatophyte species recovered from patients in Amritsar to antifungal agents; Itraconazole, Terbinafine and Fluconazole. Methodology: A total of 140 isolates of dermatophytes recovered from the superficial mycoses were examined. Broth microdilution method M38–A2 approved protocol of CLSI for filamentous fungi was followed for determining the susceptibility of dermatophyte species. Results: Trichophyton mentgrophyte was found to be the most common species followed by Trichophyton ruum.Itraconazole was found to be the most effective drug followed by Terbinafine while Fluconazole was found to be the least effective drug in vitro. Conclusion: The MIC values observed in the present study based on standard protocol might serve as reference for further studies. Such studies also reflect on the acquisition of drug resistance among isolates of dermatophyte species based on MIC values.