IJSR - International Journal of Scientific Research

Dr. Vijay Kapse; Dr. Vanita Bhaskar; Dr. Renuka Gahine; Dr. Apurva Agrawal

Volume : VIII, Issue : VIII, August - 2019

Prevalence of hemoglobin S trait among blood donors in tertiary care center of central India– a cross–sectional study

Dr. Vijay Kapse, Dr. Vanita Bhaskar, Dr. Renuka Gahine, Dr. Apurva Agrawal

Abstract :

Background: Sickle cell trait (SCT) or Hemoglobin S (HbS) trait is due to inheritance of an abnormal hemoglobin (Hb) gene from one parent and a normal gene from the other. Individuals with SCT may find themselves in the blood donor population without knowing their ‘carrier’ status and this may have severe consequences on health of a recipient, particularly if they happen to be a sickle cell disease patient. The aim of the study is to determine the prevalence of HbS trait among blood donors. Result: This cross–sectional study was performed for two years and 1 month i.e November 2016 to November 2018. A total of 36093 healthy blood donors were included in the study. Total Replacement Donor (RD) were 21941 (60.7%) and 14152 (39.20%) were voluntary Donors (VD). Two (2) ml of venous blood was collected from each donor into K3EDTA tubes and analyzed using Solubility test and confirmed by Hb Electrophoresis study. Out of 36093 blood donors 874 (2.42%) donors were found positive for Sickle Cell Trait. Conclusion: The results of the study showed the existence of SCT among the blood donor population sampled. Taking blood from such people can harm health of the recipient if they happen to be Sickle Cell Disease (SCD) patients. It is therefore recommended that blood donors as well as donated blood units should be screened for SCT to avoid causing any harm to the recipient