Volume : IX, Issue : I, January - 2020

Prevalence Of Sickle Cell Diseases In Tribal Patients By Using High Performance Liquid Chromatography

Dr. Jitendra Kumar Singh, Dr. Sunil Kumar Mahto, Dr. Devendu Bose, Dr. Shweta Kumari

Abstract :

The inherited disorders of blood include sickle cell diseases as one of the major public health problem in India. The Hemoglobin sickle (HbS) syndrome is frequently seen in various part of Jharkhand. It includes– Sickle cell disease, sickle cell trait, sickle cell β thalassemia. The tribes of Jharkhand consist of 32 tribes inhabiting the Jharkhand state in India. Automated cation–exchange High Performance Liquid Chromatography (HPLC) has emerged as an excellent screening tool for diagnosing these abnormal hemoglobin/thalassemic states. The present study is carried out to correctly diagnose the sickle cell diseases by performing HPLC and family studies if possible, and to generate data so that health care resources can be successfully planned and targeted at them. The present study was done at the Department of Pathology, Rajendra Institute of medical sciences, Ranchi between July,2018 to September 2019. Majority (41.7%) of cases were found below the age group of 10 years. Most of them (43.3%) were found to have sickle cell trait. Pallor was the commonest feature among all the age groups, majority having Hb level in between 7–9.9 gm %. 20.0% of cases showed consanguinity. HPLC is reliable, reproducible, and in many cases superior to conventional hemoglobin electrophoresis for the detection and identification of hemoglobin variants.

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

PREVALENCE OF SICKLE CELL DISEASES IN TRIBAL PATIENTS BY USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY, Dr. Jitendra Kumar Singh, Dr. Sunil Kumar Mahto, Dr. Devendu Bose, Dr. Shweta Kumari INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-1 | January-2020

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