Profile of Serological, Haematological And Biochemical Dynamics In Dengue Fever

Mohd. Siddique Ahmed Khan; Mohd.Ibrahim Shaikh; Shaikh Mahmood; Mymoona.SK

Volume : VI, Issue : XI, November - 2017

Profile of Serological, Haematological And Biochemical Dynamics In Dengue Fever

Mohd. Siddique Ahmed Khan, Mohd. Ibrahim Shaikh, Shaikh Mahmood, Mymoona. Sk

Abstract :

Aim: The objective of this study is to determine serological, haematological and biochemical dynamics to use results to predicts the severity of dengue fever and early treatment of affected patients. Method: A total number of 308 patients with clinical and serological diagnosis of fever were admitted in Shadan Institute of Medical Sciences,Teaching Hospital and Research Center, Hyderabad, Telangana, India.The patients were allotted to two groups according to age under 15 years old (n = 132) and 15 years or older (n = 176). The serological, haematological and biochemical parameters were analysed. Dengue is caused by one of the four serotypes of the dengue virus (DEN–1, DEN–2, DEN–3, and DEN–4). Also referred to as an arbovirus (arthropod – borne virus) that belongs to the genus Flavivirus of the family Flavivirdae. 1–3. The tests analysed were serological immunoglobulins(IgG, IgM, IgA & NS1 ) blood count, platelets count, serum total proteins, total bilirubin,aminotransferases, alkaline phosphatase, gamma glutamyl transferase, lactate dehydrogenase concentrations and the duration of prothrombin and activated partial prothrombin time. Results: Elisa IgG, IgM, IgA antibodies against dengue virus and NS1 dengue antigen in human by captured method are found positive for Dengue Virus. The blood count, platelets count, serum total proteins, total bilirubin, aminotransferases, alkaline phosphatase, gammaglutamyl transferase, lactate dehydrogenase concentrations and the duration of prothrombin and activated partial prothrombin time were found elevated . Conclusion: These results are relevant in assessing the disease because they can be used as positive markers for more severe forms and can help by enabling the adaption of the conduct to the need of individual patients.