PROGNOSTIC SIGNIFICANCE OF SERUM LDH AND CSF LDH IN CEREBRAL MALARIA AND VIRAL ENCEPHALITIS.

Dr. Sarita Behera; Dr. Sanjay Kumar Tirkey; Dr. Prasanna Kumar Rathor; Dr. Sushanta Kumar Bhuyan

Volume : VII, Issue : VIII, August - 2018

PROGNOSTIC SIGNIFICANCE OF SERUM LDH AND CSF LDH IN CEREBRAL MALARIA AND VIRAL ENCEPHALITIS.

Dr. Sarita Behera, Dr. Sanjay Kumar Tirkey, Dr. Prasanna Kumar Rathor, Dr. Sushanta Kumar Bhuyan

Abstract :

Background: Cereal malaria and viral encephalitis are two life threatening infections having similar presentation and difficult to diagnose in absence of parasite by slide test or rapid diagnostic test and negative serological test in case of viral encephalitis and difficult to predict their prognosis.

Objective:To study the prognostic significance of serum lactate dehydrogenase (LDH) and CSF LDH in patients of cereal malaria and viral encephalitis.

Method:After fulfilling exclusion criteria,35 encephalitis patients and 22 cereal malaria patients are selected clinically and subjected to blood MP, Rapid Diagnostic Test(RDT) and serological tests for Herpes simplex virus(HSV)–1 and HSV–2. Controls are selected from the patients having minor surgical ailment like hernia, hydrocele without neurological, renal, hepatic or cardiac diseases who were to undergo the required surgery. Serum and cereospinal fluid (CSF) LDH estimation was carried out and the observations were analysed statistically.

Results:There was no significant difference of mean serum LDH level in patients with cereal malaria or encephalitis but a significantly higher value was observed in both cases compared to controls. Mean serum LDH value was not significant among survivors and nonsurvivors of both the groups. CSF LDH was significantly high in viral encephalitis compared to cereal malaria (P< 0.0004) and controls (P< 0.001). However CSF LDH values in cereal malaria was significantly high compared to controls (P<0.001). Mean CSF LDH level in viral encephalitis was significantly high in non survivor compared to survivor. No such difference was observed in cereal malaria.

Conclusion:CSF LDH has prognostic significance in viral encephalitis but not in cereal malaria. Serum LDH is raised both in cereal malaria and viral encephalitis but having no significant difference between them and it has no prognostic value.