Prognostic value of Human Chitinase 3–like 1 in adult Acute Myeloid Leukaemia

Ashraf M. El Hefni; Asmaa H Esh; Huda F. Ebian

Volume : IV, Issue : VII, July - 2015

Prognostic value of Human Chitinase 3–like 1 in adult Acute Myeloid Leukaemia

Ashraf M. El Hefni, Asmaa H Esh, Huda F. Ebian

Abstract :

Human Chitinase 3–like–1(YKL40) secreted by cancer cells, macrophages, and neutrophils, plays role in angiogenesis, differentiation and metastasis also associated with poor prognosis in solid carcinomas,short recurrence–free interval and short overall survival. The aim of this workwas toevaluatethe role of human Chitinase 3–like 1 in adult patients with acute myeloid leukemia and its relation to other prognostic factors and treatment response.Patients and methodsThis study conducted with eighty six de novo AML patients their age ranged 18 to 60 years with median age thirty seven years and serum human Chitinase 3–like–1(YKL40)concentration was determined by a two–site, sandwich–type ELISA.Results: The results of this study revealed thatserum YKL40 was high in seventy cases (81.4%)andsignificant association with treatment response was detected (p< 0.05),a significant relation between the mean value � S.D of serum level of YKL40 in acute myeloid leukemia patientsand the apparently healthycontrol was detected, also before and after chemotherapy and responders who achieved complete remission, however there was increment of the mean value of serum YKL–40 after failure of remission induction(Non responder) with insignificant p value (0.799 ).overall survival in patients with high initial levels of serum YKL–40 was significantly less than those with normal serum levels of YKL40 (P<0.03) and disease free survival was significantly higher in patients with initially normal serum levels of YKL–40 with p value < 0.05 and there was also a highly significant relation between disease free survival and overall survival in those responders to treatment and Non responders.ConclusionHuman Chitinase 3–like–1was a novel biomarker for predicting outcome and survival in acute myeloidleukemia patients and normalization of initially high plasma YKL–40 was an important sign of response