Volume : V, Issue : VIII, August - 2016

Prognostic value of serum cholinesterase in organophosphate poisoning.

Dr Aher Sangeeta, Dr Pendore Sainath

Abstract :

 Background:Organophosphorous (OP) poisoning is one of the most common poisonings seen in India. OP compounds act through inhibition of enzyme acetylcholinesterase and estimation of pseudocholinesterase (PCE) activity strengthens the diagnosis in clinically uncertain cases of OP poisoning. OBJECTIVE: To determine whether serum cholinesterase level has a prognostic value in organophosphorus poisoning. DESIGN: Cohort (prospective) prognosis study. SETTING: Tertiary hospital in Mumbai .Materials and Methods: A prospective study conducted in Department of Medicine over period of 1 year. Diagnosis of OP poisoning was based on clinical history of exposure to OP compound and low serum pseudocholinesterase levels. MEASUREMENTS: Serum cholinesterase level was measured in all patients at the time of hospital admission. Patients of suspected OP poisoning of age >18 years admitted to emergency unit at a tertiary healthcare centre were enrolled. Serum PCE level was estimated at the time of admission in all patients and severity of OP poisoning was assessed according to PCE level. Results: The age of the patients varied from 20 to 70 yrs with 65% of them between 21–30 age groups. Majority of cases were young male, with F/M ratio 1:3.S. PCE levels were reduced in all the cases and the mean level was 3,154.16 ± 2,562.40 IU/L. Mortality rates were higher in younger people and in patients associated with lower pseudocholinesterase level (P<0.001). Conclusion: This study highlights the importance of rapid diagnosis, and initiation of early and effective treatment, which may result in less number of complications and also decrease the mortality rates.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr Aher Sangeeta, Dr Pendore Sainath Prognostic value of serum cholinesterase in organophosphate poisoning. International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016

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