Propofol infusion with midazolam premedication versus propofol infusion only for induction of anaesthesia: A comparative study

Dr. Debashish Ghosh; Dr. Dewendra J Gajbhiye; Dr. Parikshit Singh; Dr. Harjot Singh

Volume : VIII, Issue : X, October - 2019

Propofol infusion with midazolam premedication versus propofol infusion only for induction of anaesthesia: A comparative study

Dr. Debashish Ghosh, Dr. Dewendra J Gajbhiye, Dr. Parikshit Singh, Dr. Harjot Singh

Abstract :

Background: Propofol is a popular anaesthetic agent used for induction. However, it causes cardiorespiratory depression in vulnerable patients. Methods: In this study, fifty patients were randomly allocated into two groups receiving Inj. midazolam 0.03 mg/kg five minutes before induction with propofol infusion (Gp I) and only propofol infusion (Gp II).Total dose of propofol required for induction was noted. Haemodynamic parameters were noted from baseline till 10 minutes post laryngoscopy & intubation. Results: In comparison with bolus dose of propofol for induction, the reduction in the dose of propofol in group–I and group–II was 0.71mg/kg and 0.30 mg/kg respectively. The reduction in the dose of propofol in group I as compared to group II was 0.41 mg i.e.24.06% which is statistically highly significant (P<0.001). No statistically significant changes in haemodynamic parameters were observed (p>0.05) Conclusion: Propofol infusion with midazolam premedication for induction of anaesthesia is more advantageous technique.