Prospective Randomized Double Blinded Comparison of Intrathecal Isobaric 0.5% Ropivacaine and Combination of Isobaric 0.5% Ropivacaine with 45 Microgram Clonidine in Lower Limb Surgery

Dr Sumeet Chugh; Dr Shakti Singhal

Volume : VII, Issue : V, May - 2018

Prospective Randomized Double Blinded Comparison of Intrathecal Isobaric 0.5% Ropivacaine and Combination of Isobaric 0.5% Ropivacaine with 45 Microgram Clonidine in Lower Limb Surgery

Dr Sumeet Chugh, Dr Shakti Singhal

Abstract :

Background:Ropivacaine a long–acting amide local anaesthetic agentwas developed for the purpose of reducing potential toxicity and improving relative sensory and motor block profiles.Clonidine, an alpha–2 adrenergic agonist, when added to subarachnoid local anaesthetic improves intensity & duration of sensory & motor block.⁸

Aims and objectives: To find out the efficacy & safety of 15 mg of 0.5% isobaric Ropivacaine with 45 �g Clonidine for subarachnoid block in patients posted for lower limb orthopaedic surgery.

Materials and methods: 2 equal groups of 30 each were formed by computer generated randomization ; Group R (n=30) received15 mg of 0.5% (3ml), isobaric Ropivacaine + 0.3ml Normal Saline and Group RC (n=30)¹⁸received 15 mg of 0.5% (3ml), isobaric Ropivacaine + 45 �g , (0.3ml) of preservative free Clonidine.

Results:There was statistically significant difference in time required for onset of sensory as well as motor blockade, duration of sensory and motor block and rescue analgesia, in group R and group RC (P < 0.05).Conclusion:Addition of intrathecal 45 �g Clonidine prolonged sensory blockade & postoperative analgesia of isobaric Ropivacaine safely.