PROSPECTIVE STUDY ON ROLE OF COLLAGEN GRANULES IN MANAGEMENT OF CHRONIC NON HEALING ULCERS

Dr. A.Sai Datta; Dr. N.Ranjith Kumar; Dr.N.N.L.Rajitha; Dr. K.Anand kumar; Dr. T. Deepak Meher

Volume : VIII, Issue : VI, June - 2019

PROSPECTIVE STUDY ON ROLE OF COLLAGEN GRANULES IN MANAGEMENT OF CHRONIC NON HEALING ULCERS

Dr. A. Sai Datta, Dr. N. Ranjith Kumar, Dr. N. N. L. Rajitha, Dr. K. Anand Kumar, Dr. T. Deepak Meher

Abstract :

Background: Ulcers over the foot, ankle, and leg are the common problems faced by the surgeons. Leg ulceration has been a recognized public health problem for centuries.Present day hospital statistics in days of hospitalization for ulcers are similar to those in 1800s. Average length of hospital stay for ulcer patients is higher than patients admitted for other conditions and range between 18 and 121 days.(1, 2,3) what has changed over last two centuries is age distribution of ulcer patients suggesting difference in underlying aetiology for leg ulcer.(4)chronic wounds are wounds that have failed to proceed through an orderly and timely reparative process to produce anatomic and functional integrity over a period of 3 months.(5) The development of ulcer in a leg is a complex process and dependent mainly on underlying circulatory status of patient�s lower limbs. Many studies have been conducted to assess the percentage of ulcer patients with each ulcer type. (1,6–30). Wound healing is a complex process involving a number of chemical and biological events. Collagen serves as the key extra cellular component for repair and remodeling of skin tissue. As a biomaterial, collagen offers several advantages over traditional dressings, growth hormones and biological coverings(13). The use of collagen as a drug delivery system is very comprehensive and diverse. Due to its excellent biocompatibility and safety, the use of collagen in biomedical application has been rapidly growing and widely expanding to bioengineering area. Objective:To compare the rate of healing process in non healing ulcers using collagen particles with those of conventional methods. To compare the bacterial growth in wounds with collagen particle dressing to that of wounds with conventional method of dressing. Results : In this study it was observed that mean Wound Bed Score at the end of 4 weeks was 14.88 in collagen group against 11.86 in control group with significant statistical difference p<0.0001.There was significant statistical difference p<0.0001in the mean Time of wound healing in Collagen group 22.5 days,where as in control group it was 31.4 days Conclusion : Collagen based dressing showed better results like faster healing,less antibiotic usage and less pain and discomfort