Protective Effect of Hesperidin Agains Neurobehavioral Disorders And oxidative Stress in The Diabetic Ratte Gestante Strain Wistar

Chouba Ibtissem; Nessaibia Issam; Haloui Meriem; Tahraoui Abdelkrim

Volume : III, Issue : XI, November - 2014

Protective Effect of Hesperidin Agains Neurobehavioral Disorders And oxidative Stress in The Diabetic Ratte Gestante Strain Wistar

Chouba Ibtissem, Nessaibia Issam, Haloui Meriem, Tahraoui Abdelkrim

Abstract :

Our problem is to evaluate the behavioral effects of infection and combination diabetes – infection in pregnant rats and the protective effect of an antioxidant on neurobehavioral alterations and complications. Diabetes was induced by a single intraperitoneal injection of streptozotocin ( STZ ) at a dose of 60 mg / kg . The hesperidins, a natural flavonoid was administered orally (gavages) at a dose of 100 mg / kg. This administration reduces anxiety and reduces damage due to hyperglycemia associated with a significant decrease in the rates of reduced glutathione (GSH) and maternal liver on the other hand, by increasing the activity of glutathione S– transferase (GST) hepatic mother, biomarkers of oxidative stress. The results indicate the ability of hesperidin to prevent changes induced by experimental diabetes.