Volume : V, Issue : XII, December - 2016

PROTECTIVE EFFECT OF TAURINE AGAINST PROPANIL INDUCED NEPHROTOXICITY IN MICE

Arti Chauhan, Usha Gaur

Abstract :

 Objective: ?e aim of this study was to investigate the protective effects of taurine on propanil–induced alterations in biochemical indices in serum and kidney of swiss albino mice. Methods: In an experimental study 24 albino mice were distributed in six equal groups of six each as follows: Control group, 100mg propanil/kg, 100mg taurine/kg, 200mg taurine/kg, propanil (100 mg/kg) + taurine (100 mg/kg), propanil (100mg/kg) + taurine200mg/kg. Treatment was via oral route and was fed once daily for 90 days. ?e levels of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) were measured to assess the nephrotoxicity and its amelioration by taurine. Results: compared to both the control groups, propanil leads to increase AST, ALT and ALP, decreased protein level and high density lipoprotein cholesterol (HDLC). Treatment by taurine caused a significant reduction in serum levels of AST, ALT and ALP. Administration of propanil to mice significantly ( < 0.05) increased lipid peroxidation levels. Glutathione (GSH), Glutathione peroxidase (GPx), Catalase (CAT) Superoxide dismutase (SOD) decreased in the kidney tissue. ?e results indicate a protective effect for taurine against propanil induced hepatotoxicity. Conclusion: the present study suggests that taurine could be an important dietary component based on its ability to attenuate propanil induced hepatotoxicity.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Arti Chauhan, Usha Gaur, PROTECTIVE EFFECT OF TAURINE AGAINST PROPANIL INDUCED NEPHROTOXICITY IN MICE, International Journal of Scientific Research, Volume : 5 | Issue : 12 |December 2016

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