PULMONARY FUNCTIONS IN PATIENTS OF BRONCHIAL ASTHMA AND ITS ASSOCIATION WITH INFLAMMATORY MARKER (hs-CRP)

Mukul Adlakha; Sujata Gautam; Sunita Mondal; Ritu Singh; Debasish Chaudhury; Asha Gandhi

Volume : VII, Issue : VIII, August - 2018

PULMONARY FUNCTIONS IN PATIENTS OF BRONCHIAL ASTHMA AND ITS ASSOCIATION WITH INFLAMMATORY MARKER (hs-CRP)

Mukul Adlakha, Sujata Gautam, Sunita Mondal, Ritu Singh, Debasish Chaudhury, Asha Gandhi

Abstract :

Asthma is a chronic inflammatory airway disorder characterised by variable degrees of airway inflammation which is possibly accompaniedby systemic inflammation. Thus, hs–CRP mayplay a role in its pathogenesis. The study was carried out to measure and correlate pulmonary functions and hs–CRP in patients of onchial asthma.Spirometry was done using Exercise Physiology System, GanshornMedizin Electronics System, Germany and hs–CRP levels were determined using ELISA kit supplied by DRG International Inc., USA. The mean value of FEV₁ was 1.63 � 0.07 lts, PEF was 3.89 � 0.20 l/s, MEF was 1.31 � 0.09 l/s and hs–CRP was 4.84 � 0.27 mg/L. A statistically significant negative correlation was found between

� FEV₁(Lts) and hs–CRP (r= –0.5649, p<0.0001)

� PEF (l/s) and hs–CRP (r= –0.5685, p<0.0001)

� MEF (l/s) and hs–CRP (r= –0.3122, p=0.0085)

This negative correlation between pulmonary functions and serum hs–CRP levels suggests that increased levels of inflammation are related to poor pulmonary function and increase in airflow limitation in patients of Bronchial Asthma.