Retrospective Study of the Clinical Profile  and Prognostic Indicators in Patients of  Alcoholic Liver Disease Admitted to a  tertiary Care teaching Hospital

Dr. Cecil Parmar; Dr. Monark Vyas

Volume : II, Issue : XI, November - 2013

Retrospective Study of the Clinical Profile and Prognostic Indicators in Patients of Alcoholic Liver Disease Admitted to a tertiary Care teaching Hospital

Dr. Cecil Parmar , Dr. Monark Vyas

Abstract :

Background : Alcohol is the most common substance abused. Liver disease caused by alcohol abuse, including its end stage, cirrhosis, is a major health care problem, which is difficult to treat. Objectives: To study the demographic profile, laboratory parameters, complications and their prognostic implications among patients of alcoholic liver disease (ALD). Materials and Methods: Records of all patients of ALD admitted from January1, 2011 to December 31, 2012 were studied and followed up to December 31, 2013. A total of 100 patients were analyzed. Their clinical profile and laboratory parameters were noted and analyzed. Results: Among the 100 patients, 98% were male. The mean age of presentation was 48 years. Jaundice (60%) was the most common presentation followed by hepatomegaly (40 %). Hypoalbuminemia (70%) followed by ascites (30%) were common complications. Death occurred in 24 % of the patients, the most common cause being hepatic encephalopathy (70%) followed by variceal bleeding and hepatorenal syndrome. Patients had significantly increased mortality along with high aspartate aminotransferase,Alanine aminotranferase ≥ 2, ultrasonography –proven cirrhosis, rise in prothrombin time ≥6 s, total bilirubin ≥ 10 mg/dL. Conclusion: ALD was predominantly seen among the middle age group with a high morbidity and mortality. Jaundice, ascites, hepatic encephalopathy at presentation and , AST:ALT ≥ 2, USG–proven cirrhosis, coagulopathy, hyperbilirubenemia are poor prognostic indicators.