Volume : VII, Issue : V, May - 2018

ROLE OF C4d IMMUNOSTAINING IN DIAGNOSIS AND PROGNOSIS OF ACUTE AND CHRONIC RENAL ALLOGRAFT REJECTION

Pallavi Arvind Patil, Swapnil Karnik

Abstract :

Renal allograft biopsy is the gold standard for diagnosis of rejection. Incorporation of C4d as a marker for humoral rejection is a major addition for Banff Schema, 2005. We evaluated the pattern of C4d staining in indicated renal allograft biopsies from January 2009 to March 2012. There were total 108 renal allograft biopsies received in the department; out of which 59 biopsies had features consistent with rejection.

Although C4d staining was performed in all the 108 biopsies; only those with histological suspicion of rejection were included for deriving the actual percentage of C4d positivity. Morphologic features like peritubular capillary dilatation, tubulitis and interstitial inflammation were seen more frequently in C4d–positive biopsies   .  Cases with features of ATN, cellular rejection, Transplant glomerulopathy were included. Among the 59 cases, 24 (40.67%) cases were C4d positive.

90% of C4d positive cases eventually lost their grafts and the remaining 10 % became dialysis dependent.

 Thus from our study we can conclude that C4d positivity is an indicator of Antibody mediated rejection and indicates grave prognosis.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Pallavi Arvind Patil, Swapnil Karnik, ROLE OF C4d IMMUNOSTAINING IN DIAGNOSIS AND PROGNOSIS OF ACUTE AND CHRONIC RENAL ALLOGRAFT REJECTION, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-5 | May-2018

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