Volume : II, Issue : II, February - 2013

Role of Fibrinolytic Therapy in Empyema Thoracis – A Hospital Based one year Cross Sectional Study

Dr. Girish. L. D, Venkat K. P, Dr. Dr. Isaac M, Dr. Dr. G S Gaude

Abstract :

AIM: This study was carried to study the safety and efficacy of fiinolytic therapy in Indian patients with empyema thoraces. MATERIALS AND METHODS: A total of 67 patients studied in a tertiary care hospital over a period of one year. The patients with empyema or Para pneumonic effusions were included in the study. The patients were then divided in to two groups in 2:3 randomly Group I (control) who received ICTD (Intercoastal Drainage Tube) alone with instillation of normal saline for 5 days, Group II (study) receive ICTD (Intercoastal Drainage Tube) alone with instillation of streptokinase (STK) 2.5 L Units daily for 5 days, all the patients in both groups received antibiotics irrespective of the culture and sensitivity reports. RESULTS: Majority of the patients were in the age group of 31-40 years (27 cases) and total numbers of males included were 45 and total numbers of females included were 17. The major complains of the patients included are fever (88 %), chest pain (75%) dyspnea (56.4%) and weakness (79%) other minor symptoms are cough (22.5), productive cough (51.6%), shoulder pain (17.7 %). It is clear from this study that streptokinase treatment reduced the necessary for surgical intervention, so overall safety of intrapleural streptokinase infusion is safe and decreases the need for surgical intervention. CONCLUSION: In conclusion, this study has shown that the intrapleural streptokinase at a dose of 2.5 lakh I U daily for five days is safe and effective in improving the catheter drainage of infected pleural effusions, without any obvious systemic effects.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Girish.L.D,Venkat k. P,Dr. Dr.Isaac M,Dr. Dr.G S Gaude Role of Fibrinolytic Therapy in Empyema Thoracis – A Hospital Based one year Cross Sectional Study International Journal of Scientific Research, Vol.II, Issue.II February 2013

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