Volume : VII, Issue : VII, July - 2018

Role of Immunohistochemistry in the diagnosis of Hirschsprung Disease.

Dr. Muktanjalee Deka, Dr. Surajit Kumar Roy

Abstract :

 Hirschsprung disease constitutes one of the important causes of intestinal obstruction in the pediatric age group. Males are affected more than

females. The classic and short segment Hirschsprung disease is the most common type of Hirschsprung disease and the rectosigmoid colon is the
most common site for this disease , the patients most commonly present with clinical manifestation of intestinal obstruction such as delayed
passage of meconium, constipation etc. Though histopathological examination is the gold standard , Calretinin is reliable in detecting the presence
or absence of ganglion cells . It has many advantages that it can be carried out in paraffin embedded tissue sections. Also binary pattern of
interpretation; negative indicates a diagnosis of Hirschprung disease and positive rules out the diagnosis of Hirschsprung disease. Thus calretinin
can be a valuable cost effective diagnostic aid for diagnosis of Hirschsprung disease.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Muktanjalee Deka, Dr. Surajit Kumar Roy, Role of Immunohistochemistry in the diagnosis of Hirschsprung Disease., INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-7 | July-2018


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