Volume : VII, Issue : VI, June - 2018

ROLE OF INSULIN RESISTANCE IN PREGNANCY INDUCED HYPERTENSION

Arshia Zeib, Arshiya Fatima, N. Vani

Abstract :

Background & Objectives:Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Preeclampsia is frequently described as a state of insulin resistance. Insulin resistance features like hypertension, hyperinsulinemia, glucose intolerance and lipid abnormalities are associated with pregnancy induced hypertension.Due to the effect of insulin on epithelium and smooth muscle, hyperinsulinemiacauses vascular resistance by inducing endothelial dysfunction or smooth muscle hypertrophy.It also stimulates release of epinephrine and thus increasing blood pressure.Aim of the study is to evaluate insulin resistance as a causative pathogenesis factor of PIH.

Methods: A case control study was done with 90 patients divided into 2 groups (normotensive pregnant women as controls, pregnancy induced hypertension as cases). Fasting levels of Plasma Glucose and Serum Insulin were estimated. IR was calculated by HOMA–IR formula. Data was analyzed using unpaired t– test.

Results: In the present study women with PIH had significantly higher values of Serum Insulin(50.47 ± 24.59),IR(10.65 ± 5.22), , FBS(86.21 ±11.13, 0.007) as compared to normotensive pregnant women. Serum Insulin(10.28 ± 5.98), HOMA IR(1.97 ± 1.28), FBS(80.26 ± 8.69, p value 0.007) with p value of < 0.0001.

Interpretations & Conclusion: The PIH women exhibited significant increase in serum Insulin levels, HOMA IR, FBS. These observations suggest the possibility that insulin resistance may be involved in pathogenesis of PIH. Therapeutic approach to improve insulin sensitivity may help in prevention or treatment of PIH.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Arshia Zeib, Arshiya fatima, N.Vani, ROLE OF INSULIN RESISTANCE IN PREGNANCY INDUCED HYPERTENSION, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-6 | June-2018

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