Role of Low HDL cholesterol in Ischemic stroke Retrospective Study

DR.B.Sudarsi; Dr.R.Siddeswari; Dr.Shiva Prasad; Dr.N.Srinivas

Volume : V, Issue : VI, June - 2016

Role of Low HDL cholesterol in Ischemic stroke Retrospective Study

Dr. B. Sudarsi, Dr. R. Siddeswari, Dr. Shiva Prasad, Dr. N. Srinivas

Abstract :

 Background: Dyslipidemia is one of the important cause for ischemic stroke. Low HDL–C pose a greater risk for ischemic stroke .Objective of the present study is to study the association of low–HDL–C in ischemic stroke. Materials& Methods: This is a retrospective study of 100 patients of ischemic stroke admitted in Osmania general hospital(OGH), Hyderabad. Detailed history was taken and complete clinical examination was done in all patients who were admitted with ischemic stroke. Computerised Tomography/Magnetic Resonance Imaging ain was done. 5ml fasting venous blood was collected and used for the measurement of lipid profile and creatinine. Patients with malignant disease, renal disease, thyroid disorder, liver disease and hemorrhagic stroke were excluded from study. Results: Total 100 subjects of both sexes of ischemic stroke were included. Among them 69 were males and 31 were females. Patients with age <40years were 6 and age≥40years were 94. Among them 59 were hypertensives, 22 were diabetics, 43 were smokers and 42 were alcoholics. Number of patients with HDL–C(High density lipoprotein cholesterol) <40mg/dl are 72, non HDL–C >130 mg/dl were 31 (31%), ratio of Total cholesterol/HDL–C <2 is one , 2–3.99 were 37, 4–6 were 49, >6 were 13. The mean HDL–C is 33.8+/–10.4 mg/dl. Mean TC (total cholesterol) is 147.2+/–47.4 mg/dl. Mean triglycerides is 119.1+/–48.8mg/dl. Mean LDL–C (low density lipoprotein cholesterol) is 89.3 +/–39.2 mg/dl. Mean non HDL C is 113.4 +/–44.7 mg/dl. Conclusion: Low HDL–C levels pose a greater risk to stroke and the ratio of TC/HDL–C above 2 is probably a better indicator for ischemic stroke