Volume : VII, Issue : XI, November - 2018

ROLE OF NUCHAL TRANSLUCENCY (NT) AT 11-14 WEEKS OF GESTATION AS A SCREENING TOOL TO IDENTIFY FETAL ABNORMALITIES

Mhapankar Sabrina, Goli Ajita, Monga Parul

Abstract :

 

The present study was conducted to establish the role of Nuchal translucency as a screening tool for identifying patients at risk for chromosomal and congenital abnormalities and to ascertain its value in planning further management in cases of abnormal Nuchal Translucency. 200 pregnant women, between 11–14 weeks of gestation as per the inclusion and exclusion criteria were included in this study. A detailed history and clinical examination was followed by counselling and ultrasonography by trained sonologists. If NT > 95th centile for that gestational age, the women were considered to be at high risk (screen positive) of having aneuploidy/cardiac defects/other structural defects and hence these women were offered karyotyping.If karyotyping was normal, then follow up was done with an anomaly scan at 20–22 weeks of gestation.If lethal anomaly detected at anomaly scan, pregnancy was terminated. If no congenital anomalies picked up, fetal echocardiography done to detect any congenital cardiac defect.If no lethal cardiac defect detected, pregnancy was continued and followed by term scan. After delivery, the baby was evaluated by the pediatrician for anomalies. Ultrasound findings along with nuchal translusency and the pregnancy outcome were noted.

RESULTS

In this study, majority of the women were between 21–25 years of age, equal distribution between primigravida and multigravida, majority of the women were screened between 12–14 weeks of gestation. (37% between 12.1–13 weeks, 33% between 13.1–13.6 weeks), 22% of pregnant women had significant risk factors in the past obstetric history (e.g.; previous history of fetal anomalies, previous history of Down’s syndrome, previous history of unexplained fetal loss).96.5% of pregnant women had normal nuchal translucency (i.e., NT<95th centile),  7 patients(3.5%) with increased nuchal translucency (NT>95th centile) had true positive results. However, 4 patients were found to have false negative results. Overall, our study showed 100% specificity with 10% fetus showing true positive results and 60% sensitivity with 4 fetus having false negative results. Positive predictive value was 100% and false positive rate was 0%.

Conclusion :fetal abnormalities are significantly related to increased NT.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

nuchal translusency, aneuploidies, Mhapankar Sabrina, Goli Ajita, Monga Parul , INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7|Issue-11| November-2018


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