Role of plasma Nterminal proBtype natriuretic peptide (NTproBNP) level in differentiating cardioembolic stroke from other stroke subtypes

Dr Pushpendra Nath Renjen; Dr. Mirza Atif Beg; Dr. Dinesh Chaudhari; Dr Rajender Singla

Volume : VI, Issue : X, October - 2017

Role of plasma Nterminal proBtype natriuretic peptide (NTproBNP) level in differentiating cardioembolic stroke from other stroke subtypes

Dr Pushpendra Nath Renjen, Dr. Mirza Atif Beg, Dr. Dinesh Chaudhari, Dr Rajender Singla

Abstract :

BACKGROUND: NT–proBNP is a well–recognized biochemical marker of congestive heart failure. Recent studies suggested that NT–proBNP may be used as a marker of cardioembolic stroke.

OBEJECTIVE: To study the value of N–terminal proB–type natriuretic peptide in differentiating cardioembolic stroke from other subtypes of stroke.

MATERIAL & METHODS: A total of 108 consecutive patients presenting with acute ischemic stroke within 72 hours of onset of stroke were studied. They were classified in to four groups: Cardioembolic (CE), Large artery atherosclerosis (LAA), Small–vessel disease (SVD) and other subtypes. Serum NT–proBNP levels were assessed.

RESULTS: Out of 108 patients, 28(25.9%) were cardioembolic whereas 74.1% patients were in non–cardioembolic (NCE) group. The levels of NT–proBNP were significantly high in CE group (839.2�491.6 pg/ml) vs NCE group (153.96�144.25pg/ml) (p value<0.001).

CONCLUSION: Our results showed that NT–proBNP level estimation as a biomarker has an acceptable diagnostic value in distinguishing cardioembolic stroke from other subtypes.