ROLE OF PROPHYLACTIC ONDANSETRON FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN LOWER SEGMENT CAESAREAN SECTION

DR MANOHAR LAL KANWARIA; DR ZARA WANI; DR ANUMEHA JAIN

Volume : VII, Issue : III, March - 2018

ROLE OF PROPHYLACTIC ONDANSETRON FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN LOWER SEGMENT CAESAREAN SECTION

Dr Manohar Lal Kanwaria, Dr Zara Wani, Dr Anumeha Jain

Abstract :

Objective: To determine the efficacy of prophylactic administration of intravenous Ondansetron for prevention of spinal anaesthesia induced hypotension in lower segment caesarean section.

Material and Methods: One hundred patients were selected for this study, and randomly divided in two groups of 50 each, using random numbers table. Both groups were preloaded with Ringer�s lactate at dose of 10ml/kg. Group A received 04 mg of IV ondansetron 5 min prior to spinal anaesthesia, whereas Group B received normal saline 05 minutes before administration of Spinal Anaesthesia.

Results: Average age of Group A was 28.62 � 4.64 years, whereas that of Group B was 27.88 � 3.98 (p–value= 0.394). Average weight of Group A was 70.30 � 6.25 kg, whereas that of Group B was 70.74 � 6.17 kg (p–value= 0.724). Hypotension was noted in 21 patients in group A (42%), whereas it was observed in 34 Patients in Group B (68%) (p–value= 0.009). Bradycardia was noted in 9 patients in Group A (18%) and 19 patients in Group B (p=0.026).

Conclusion: Intravenous administration of 04 mg of intravenous ondansetron, 05 minutes prior to subarachnoid block, is effective in decreasing frequency of hypotension.