Routine Histopathologic Examination Of Cholecystectomy Specimens–Role In Detection Of Epithelial Neoplasms Of The Gall Bladder

Bhavna Nayal; Ranjini Kudva; Ashitha Nanaiah; Rajesh P Nair

Volume : IV, Issue : II, February - 2015

Routine Histopathologic Examination Of Cholecystectomy Specimens–Role In Detection Of Epithelial Neoplasms Of The Gall Bladder

Bhavna Nayal, Ranjini Kudva, Ashitha Nanaiah, Rajesh P Nair

Abstract :

Introduction: Adenomas and dysplasias of the gall bladder are premalignant lesions which have been proposed to progress to carcinoma through different pathways. There is an increase in the incidence of detection of these lesions in routine cholecystectomy specimens. This study was carried out to study the clinicopathologic characteristics of gall bladder epithelial neoplasms. Materials and methods: A retrospective study of all patients diagnosed with adenoma, dysplasia and carcinoma in a tertiary care hospital between September 2011 and September 2014 was done. The clinical and histopathological features were studied. Results: Twenty four cases of gall bladder neoplasms were studied with 5 cases of adenoma, 7 cases of dysplasia and 12 cases of carcinomas. The indication for cholecystectomy for majority of these patients was chronic cholecystitis associated with gall stones. The most common type of adenoma noted was tubular type with pyloric metaplasia and few were also associated with dysplasia. Dysplasia was seen in half of the patients with invasive cancers while no adenoma was noted. Conclusion: The presence of dysplasia in the mucosa adjacent to cancers, support the causal relation of dysplasia and carcinoma in the gall bladder. This further highlights the need for detection of high risk patients for early diagnosis of gall bladder neoplasms and prophylactic cholecystectomy.