SALIVARY LACTATE DEHYDROGENASE LEVELS IN ACTIVE CIGARETTE SMOKERS AND PASSIVE SMOKERS AS BIOMARKER FOR ORAL CANCER.

DR. PREM KUMAR.; DR. S. DHEEPTHASRI; DR. SANGEETA CHAVAN; DR. UMESH; DR. MUTHU KARUPPAIAH; DR. PALANIVEL PANDIAN

Volume : VIII, Issue : IV, April - 2019

SALIVARY LACTATE DEHYDROGENASE LEVELS IN ACTIVE CIGARETTE SMOKERS AND PASSIVE SMOKERS AS BIOMARKER FOR ORAL CANCER.

Dr. Prem Kumar. , Dr. S. Dheepthasri, Dr. Sangeeta Chavan, Dr. Umesh, Dr. Muthu Karuppaiah, Dr. Palanivel Pandian

Abstract :

Purpose : To assess the salivary lactate dehydrogenase levels in active , passive smokers and healthy controls as biomarker for oral cancer. Materials and Methods : The study included subjects residing in Madurai city. A total 75 Subjects were included in the study (25 active smokers , 25 passive smokers and 25 healthy controls) , informed consent were obtained from all the subjects prior to the start of the study. The source of data was primary in nature which included structured interview to collect demographic details and details regarding smoking and exposure to smoke , clinical examination and salivary analysis for assessing the LDH was done. Results: The age of the study participants ranged from 18 to 60 years . The mean LDH value for active smokers , passive smokers and healthy controls were 433U/L , 356.5U/L and 230.6 U/L respectively. There was a positive correlation between the duration , type and frequency of smoking , consumption of cigarette / beedi and LDH level among active smokers. Conclusion : The present study reveals a association between cigarette smoking (both active and passive ) and elevated salivary LDH levels. Estimation of salivary LDH level can as a serve reliable marker to monitor the tobacco smokers