SELECTIVE ESTROGEN RECEPTOR MODULATOR : EFFICACY IN ABNORMAL UTERINE BLEEDING IN PERIMENOPAUSAL WOMEN

ANKITA MANI; KANCHAN SHARMA

Volume : VIII, Issue : III, March - 2019

SELECTIVE ESTROGEN RECEPTOR MODULATOR : EFFICACY IN ABNORMAL UTERINE BLEEDING IN PERIMENOPAUSAL WOMEN

Ankita Mani, Kanchan Sharma

Abstract :

INTRODUCTION: Abnormal uterine bleeding affects 50 % women of perimenopausal age.Ormeloxifene (SERMS) plays a sheet role in management of AUB . OBJECTIVE: Study was focussed to see the effects of ormeloxifene on different kinds of endometrium as far as medical management of Abnormal Uterine Bleeding (AUB) is concerned. MATERIAL & METHODS: Study was Prospective & interventional . It was done on 90 patients attending Gynae OPD Gauhati Medical College Hospital with the complain of AUB in perimenopausal age group.(37 to 48 years).They were prescribed with ormeloxofene 60mg orally twice weekly for 3 months followed by once in a week for further 3months after doing preliminary endometrial biopsy. RESULTS : Ormeloxifene was found to be more effective in reducing PBAC score & ET in patients with proliferative and secretory endometrium .The reduction in mean PBAC score with ormeloxifene (175.3 to 20.93)(p value 0.0001) & ET (9.6 to 2.9 mm) (p value 0.0001) in proliferative endometrium ,(179.2 to 14.8(p value 0.0001) )& ET 11.1 to 1.9 mm (p value 0.0003)in secretory endometrium was observed after 6 months. However it was found ineffective in reducing PBAC score& ET in patients with atrophic endometrium .Change in PBAC SCORE from 176.4 to 150.8(p value 0.08) & in ET from 2.8 to 2.1mm( p value 0.3) was observed .No major side effects were reported.CONCLUSION: Ormeloxifene is highly effective in AUB with proliferative and secretory endometrium in perimenopausal patients.