SEROLOGICAL DIAGNOSIS OF HAV AND HEV,THEIR PREVALENCE AND ITS BIOCHEMICAL PARAMETERS CORRELATION IN CLINICALLY SUSPECTED CASES OF ACUTE VIRAL HEPATITIS

Dr. Hetal Rathod; Dr. Sanjay Rathod; Dr. Jayshri Pethani; Dr. N. M. Shaikh; Dr. Parul Shah

Volume : IV, Issue : II, February - 2015

SEROLOGICAL DIAGNOSIS OF HAV AND HEV,THEIR PREVALENCE AND ITS BIOCHEMICAL PARAMETERS CORRELATION IN CLINICALLY SUSPECTED CASES OF ACUTE VIRAL HEPATITIS

Dr. Hetal Rathod, Dr. Sanjay Rathod, Dr. Jayshri Pethani, Dr. N. M. Shaikh, Dr. Parul Shah

Abstract :

Introduction: �Viral Hepatitis� denotes a primary infection of liver by heterogeneous group of Hepatitis virus. They are clinically indistinguishable, leading to morbidity and mortality. Mainly diagnosed by serological and molecular markers. Hepatitis A and Hepatitis E viruses are transmitted by fecal-oral route and cause sporadic as well as outeaks of acute viral hepatitis. Objectives: Prevalence of HAV and HEV in patients of acute viral hepatitis along with their correlation between various clinical, serological and biochemical parameters. Materials and Methods: From December 2013 to November 2014 total 1649 and 1963 samples of suspected cases of acute viral hepatitis with icterus were tested for HAV and HEV respectively. Samples were analysed for HEV IgM and HAV IgM antibody by ELISA. Results: Out of 1649 samples, 438 (26.56%), were positive for HAV IgM with most cases in age group 1-10 years 359 (81.86%) . Out of 1963 samples 1092 (55.62%) were positive for HEV IgM with most cases in age group 21-30 yrs 458 (41.94%). Males were more affected than Females in HAV IgM and HEV IgM positive cases. Yellowish discoloration of skin and mucus memane was main presenting symptom with serum billirubin of 3.1-6.0mg/dl in 45.20% and 43 47.00% in HAV IgM and HEV IgM positive cases respectively. SGPT level of 501-750 IU/l, in 28% and 30% in HAV IgM and HEV IgM positive cases respectively. Conclusion: High prevalence rate is noted for HEV infection. Adult & paediatric age group are affected more in case of HEV & HAV respectively. Jaundice was most common clinical feature with increased billirubin & SGPT level.