Seroprevalance of TORCH Infection in women with Bad Obstetric History

Dr.Leena B.Sutariya; Dr.Saklainhaider S. Malek; Dr.Kairavi J.Desai

Volume : V, Issue : IX, September - 2016

Seroprevalance of TORCH Infection in women with Bad Obstetric History

Dr. Leena B. Sutariya, Dr. Saklainhaider S. Malek, Dr. Kairavi J. Desai

Abstract :

Introduction: Bad obstetric history (BOH) implies previous unfavourable foetal outcome in terms of two or more consecutive spontaneous abortion, history of intrauterine foetal death or growth retardation, still births, early neonatal death and/or congenital anomalies.Maternal infections transmissible in utero at various stages of gestation lead to recurrent pregnancy wastage. Infections caused by toxoplasma, rubella virus, cytomegalo virus (CMV) and Herpes simplex virus (HSV) are together called TORCH infection . Materials and Methods: After obtaining consent from total 120 pregnant women with bad obstetric history and 64 pregnant women without bad obstetric history, in sir.t.hospital, Bhavnagar, TORCH IgM and IgG antibodies were detected from the serum by ELISA test kit (DSI) .The optical density will read in the ELISA reader and results are presented as positive or negative for the antibody titer, for each of the infectious agents tested. Results: Seropositivity for toxoplasma is 36.66 %, rubella 27.50%, cytomegalovirus 36.66 %, HSV 1 and HSV 2 infection are 5% and 7.5% respectively for IgM and for IgG positivity rate for toxoplasma is 25.83%, rubella is 32.5%, cytomegalovirus is 46.66%,for HSV 1 and HSV 2 it is 1.08% and 1.33% respectively in patients with bad obstetric history. In control patients this prevalance is low.. Conclusion: Seropositivity is significantly higher in women with BOH as compared to patients without BOH. A previous history of pregnancy wastage and the serological reaction for TORCH infections during current pregnancy must be considered while managing BOH cases so as to reduce the adverse fetal outcome.