Seroprevalence and Trends of Transfusion Transmissible Infections in Blood Donors At Zonal Blood Transfusion Centre, Jodhpur, Rajasthan, India.

Ankur Gupta; Manju Bohra; Manish Mittal; Mayank Sharma; Ankesh Gupta

Volume : III, Issue : VIII, August - 2014

Seroprevalence and Trends of Transfusion Transmissible Infections in Blood Donors At Zonal Blood Transfusion Centre, Jodhpur, Rajasthan, India.

Ankur Gupta, Manju Bohra, Manish Mittal, Mayank Sharma, Ankesh Gupta

Abstract :

Background - Blood is a life saving drug. Transfusion of blood carries risk of transfusion transmitted diseases. Therefore predonation counselling of donors and screening of each unit of blood is mandatory. AimsStudy is done with aim to analyze the seroprevalance of five important infectious diseases on a total of 42121 blood donors over 4 year study period at blood transfusion centre located at Jodhpur, Rajasthan, India. Material and Methods - Each blood donor is screened for anti-human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (HCV), rapid plasma reagin (RPR) slide kit test for syphilis and card test for malarial parasites. Screening for anti-HIV, HBsAg and anti-HCV was carried out by enzyme linked immunosorbent assay (ELISA).Syphilis was tested using RPR slide kit test. Malarial parasite was tested by antigen rapid card test. Statistical Analysis - Graph pad prism software (Chi square test). Result - Study shows the overall seropositivity of 2.69%(1135/42121), while individual seropositivity for anti-HIV was 0.28%(122/42121), for HBsAg 2.03%(857/42121), for antiHCV 0.21%(91/42121), for syphilis 0.12%(51/42121) and for malaria 0.033%(14/42121). There was no statistically significant difference (p>0.05) in the seropositivity of various markers between voluntary and replacement donors except for HBsAg(p<0.05). There was statistically significant difference (p<0.05) in the prevalence of seropositivity for HIV, HCV, HBsAg, syphilis and malaria over a period of four years study. Conclusion - Study concludes that the continuous and consistent predonation counseling and blood screening and Hepatitis B vaccination in community should be mandatory.