Volume : II, Issue : VII, July - 2013

Serum biochemical changes induced by imidacloprid

S. Soujanya

Abstract :

Effect of oral administration of imidacloprid on serum biochemical parameters was studied in male rats and the protective role of vitamin C was assessed against imidacloprid-induced toxicity. Forty eight male rats were divided into four groups of 12 animals each. Group 1 served as control, while groups 2 and 4 were administered with imidacloprid (80 mg/kg b.wt/day) by oral gavage for 28 days. In addition to imidacloprid, group 4 also received vitamin C @ 10 mg/kg. Group 3 was maintained as vitamin C control. At the end of 14th day, six rats from each group and the remaining at the end of 28th day were sacrificed. Blood samples were collected before sacrifice for sero-biochemical analysis. The biochemical assays showed a significant (P < 0.05) increase in ALT, AST, serum creatinine and decrease in total protein in group 2. Co-administration of vitamin C ought moderate protection in all the above parameters.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

S. Soujanya Serum biochemical changes induced by imidacloprid International Journal of Scientific Research, Vol : 2, Issue : 7 July 2013

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