Serum ferritin correlated with deficiency of serum vitaminB12 and folic acid in Thalassemia

Dr. GARIMA GUPTA; Dr. NEHA SHARMA

Volume : VIII, Issue : V, May - 2019

Serum ferritin correlated with deficiency of serum vitaminB12 and folic acid in Thalassemia

Dr. Garima Gupta, Dr. Neha Sharma

Abstract :

Objective: To measure level of deficiency of serum vitaminB12 and folic acid its correlation with serum ferritin in Thalassemic patient. Material and Methods: The study of investigations were done in the Biochemistry department of SMS Medical college and Hospital, Jaipur. Thirty children of Thalassemia included in study group while thirty normal children in control group. Estimation of levels of folic acid,vitaminB12 and serum ferritin were made in autoanalyzer ADVIA Centaur XP analyzer. Result : The analysis of Thalassemia group compare with healthy control group show significantly low (p<0.001)values. The statistical study of Thalassemia group with healthy control group show significantly low values of (p<0.001) serum folic acid,vitaminB12 level while raised values of serum ferritin in study groups. Significant negatively correlated to serum ferritin with vitaminB12& folic acid in Thalassemia major group. Our study found significant correlation of ferritin and vitaminB12& folic acid deficiency in Thalassemia. Conclusion: The study found a significantly lower values of folic acid,vitaminB12 and higher values of ferritin level of Thalassemia patient. Biochemical evaluation of these parameters is important in Thalassemia patients of paediatric group. In upcoming time, it was require to study the further more mechanism of relationship between ferritin, vitaminB12, folic acid in these patients.