Serum levels and discriminating abilities of LDH, 5'NT, aminotransferases in mild and severe preeclampsia

Imran Ahmed Siddiqui; B.Laxmikanth; J Ramarao

Volume : VII, Issue : VI, June - 2018

Serum levels and discriminating abilities of LDH, 5'NT, aminotransferases in mild and severe preeclampsia

Imran Ahmed Siddiqui, B. Laxmikanth, J Ramarao

Abstract :

Preeclampsia (PE) is a pregnancy specific multisystem disorder characterized by heterogeneous clinical and laboratory findings. There are no clinically useful screening tests to identify the women at risk.

Aims and Objectives: To investigate serum lactate dehydrogenase (LDH) activity in PE and to evaluate the relationship between changes in serum levels of LDH, 5�nucleotidase (5�NT), aminotransferases, uricacid (UA) and urine proteins with the severity of PE and to correlate it to the pregnancy outcome.

Material and Methods: 60 women with PE and 30 women having normal uncomplicated pregnancies, matched for maternal age and gestational age were respectively recruited as cases and control groups. Serum levels of LDH, 5�NT,UA, urea, creatinine, aspartate transaminase (AST), and alanine transaminase(ALT) were estimated along with24 hours urinary proteins. The data were analyzed using SPSS software version 17.0.

Results: There was a statistically significant increase in LDH, 5�NT, UA, ALT and AST in severe and mild PE compared to controls (p<0.05). These changes were more pronounced in severe PE as compared to that of mild PE cases (p<0.05).Among all the variables, the serum LDH and ALT showed better discriminating ability for PE and its severity.

Conclusion: LDH and ALT taken together have shown highest diagnostic efficiency in discriminating PE cases from non–PE controls and are useful in assessing disease severity, as well.