Volume : VI, Issue : IX, September - 2017

Serum Paraoxonase 1 in Type 2 Diabetes Mellitus complicated with Nephropathy

Dr. Simant Baliarsingh

Abstract :

 More than one third of Type 2 diabetes mellitus patients (T2DM) may progress to the stage of nephropathy, which might be attributed to oxidative stress. Paraoxonase 1(PON 1) levels are inversely related to oxidative stress. Fifty subjects each were selected from T2DM without complications (DM), with Nephropathy (DN) and Controls. Blood samples were analyzed for PON 1, Fasting blood sugar (FBS), HbA1c and Lipid profile.   PON1 levels of the DN group were significantly decreased and of FBS, HbA1c, Total cholesterol and LDL–C levels significantly increased from the Control group (ANOVA p<0.0001). VLDL–C and Triglyceride levels were significantly lower in the Control group when compared to DN and DM groups (ANOVA p< 0.001). PON1 levels show a steep fall in diabetics going into nephropathy and therefore may act as an additional marker for the condition.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Simant Baliarsingh, Serum Paraoxonase 1 in Type 2 Diabetes Mellitus complicated with Nephropathy, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-9 | September-2017

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