Sialic Acid in Low Risk and High Risk Patients Undergoing Off Pump Coronary Artery Bypass Graft–A Comparative Study

Sindhu; Harish; Vinitha Ramanath Pai; Jyothi MP D’souza; Rakesh M Gangadhar; Neevan D’souza

Volume : III, Issue : VI, June - 2014

Sialic Acid in Low Risk and High Risk Patients Undergoing Off Pump Coronary Artery Bypass Graft–A Comparative Study

Sindhu, Harish, Vinitha Ramanath Pai, Jyothi Mp D Souza, Rakesh M Gangadhar, Neevan D Souza

Abstract :

Back ground: Coronary artery bypass graft (CABG) may be associated with inflammatory response and myocardial damage. The study compared pre-operative and post-operative sialic acid levels in both, low risk and high risk patients, undergoing CABG. Materials and Methods: Pre-operative and 24 hours post-operative blood samples were collected in low risk and high risk coronary artery disease patients scheduled for CABG and sialic acid was estimated. Results: Although post-operative protein bound sialic levels were significantly higher in both low and high risk patients undergoing CABG (pre-operative vs post-operative p<0.01), the increase was more significant in high risk group when compared to low risk group (low risk vs high risk group - pre-operative p<0.001 and post-operative p<0.001) Conclusion: Increased post-operative SA suggests that it might be useful in assessing inflammation and myocardial damage in patients undergoing CABG. SA may help in differentiating the high risk from the low risk varieties undergoing CABG.