Significance of micronuclei score as a screening tool in cervical intraepithelial neoplasia and cervical cancer

Mariya Banu Ranjini Sridharan; Dr. Reetika Sharma; Dr. Anita Ramdas

Volume : VII, Issue : V, May - 2018

Significance of micronuclei score as a screening tool in cervical intraepithelial neoplasia and cervical cancer

Mariya Banu Ranjini Sridharan, Dr. Reetika Sharma, Dr. Anita Ramdas

Abstract :

Objective : To compare and assess the score of micronuclei in a spectrum of non–neoplastic, pre–neoplastic lesions and invasive cancer of the cervix.

Materials and methods: In this retrospective study, we have assessed the micronuclei count in 48 cases in conventional pap smears. The smears were analysed by light microscopy under oil immersion (x 1000) .

Results: Mean � SD [Median ( Min –max)] for microncleated cell count were as follows : Normal – 4.50 � 2.070 [4.00 ( 2–9) ], Inflammatory – 4.38 � 2.669 [4.50 ( 1–8) ], Infections – 5.25 � 2.121 [5.00 ( 2–8)], LSIL– 7.75 � 3.327 [8.00 ( 2–14)], HSIL –11.63 � 8.193 [9.50 ( 2–28) ] and SCC – 16.25 � 4.027 [16.00 ( 11–24) ].

Conclusion: micronucleus counting can be taken as a helpful screening tool in conjunction with conventional Pap test for screening of cervical cancer.