SIGNIFICANCE OF VARIOUS BIOCHEMICAL MARKERS TO ASSESS SEVERITY OF HYPERTENSIVE DISORDERS OF PREGNANCY

Dr. Manpreet Kaur Dhillon; Dr. Gurdeep Kaur Bedi

Volume : VI, Issue : VII, July - 2017

SIGNIFICANCE OF VARIOUS BIOCHEMICAL MARKERS TO ASSESS SEVERITY OF HYPERTENSIVE DISORDERS OF PREGNANCY

Dr. Manpreet Kaur Dhillon, Dr. Gurdeep Kaur Bedi

Abstract :

Hypertensive disorders of pregnancy or Pregnancy induced hypertension (PIH) is a common gestational disorder which is associated with maternal and fetal morbidity and mortality .Yet the etiology of this disorder is little understood. Alterations in levels of liver function and renal function markers have been suggested to be linked to severity of PIH. Present study aimed to evaluate levels of various biochemical markers and their importance in assessing severity of PIH. Material and methods: 50 patients with PIH which constituted study group and 50 normotensive pregnant women constituted control group. Collected samples were analysed for uric acid , urea and creatinine levels which predict renal functions and liver transaminases (SGOT and SGPT) which predict liver functions. Result: Serum Uric acid levels significantly increased (p<0.001) , levels being 4.27�0.83mg/dl in normal pregnant women and 5.56 � 0.78 mg/dl in PIH patients. There was no difference in levels of urea and creatinine among two groups. .The increase in SGOT and SGPT levels in study group as compared to control group shows statistically significant association (p value= 0.008) .

Conclusion: Serum uric acid and liver transaminases are strongly associated with pre eclampsia, suggestive of their predictive role in assessing hepatorenal damage in patients presenting with pregnancy induced hypertension.