Volume : VIII, Issue : VIII, August - 2019

SPECIATION AND ANTIFUNGAL SUSCEPTIBILITY PROFILE OF CLINICAL CANDIDA ISOLATES

Vijay Ambade

Abstract :

INTRODUCTION: The epidemiological shift towards increase in prevalence of non–albicans Candida species, emergence of new Candida species and development of antifungal drug resistance to Candida species in global scenario made it relevant to identify Candida species with their antifungal susceptibility pattern. Hence, the present study was carried out. MATERIALS & METHODS: Present prospective study was conducted at microbiology department of M.G.I.M.S. Sevagram, Maharashtra, India from January 2010 to December 2011. A total of 128 Candida strains, from various clinical specimens were identified by standard diagnostic techniques and with HiCrome Candida differential agar. All the identified Candida strains were tested for susceptibility against four antifungal agents amphotericin B, clotrimazole, ketoconazole and fluconazole by oth microdilution method (M27–A2) as per CLSI guidelines. RESULTS: C. albicans (60.15%) were predominated over non–albicans Candida (39.85%). 3.90% isolates showed resistance to amphotericin–B, 7.03 % noted resistance to fluconazole while 3.90% isolates exhibited resistance to clotrimazole. C. Guillermondii found susceptible to all antifungal agents and none of Candida isolate found resistant to ketoconazole. CONCLUSION: Candida speciation and antifungal resistance surveillance must be essential for studying the trend of antifungal resistance in a particular area and thereby to develop rational antifungal therapy

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

SPECIATION AND ANTIFUNGAL SUSCEPTIBILITY PROFILE OF CLINICAL CANDIDA ISOLATES, Vijay Ambade INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-8 | August-2019

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